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- 保存条件：
4°C, sealed storage, away from moisture and light
- 英文名：
Pyrilamine maleate
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
59-33-6
- 规格：
10 mM * 1 mL/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥550.0 |
|---|---|---|---|
| 规格： | 100 mg | 产品价格： | ￥500.0 |
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Mepyramine maleate
CAS No. : 59-33-6
MCE 国际站：Mepyramine maleate
产品活性：Mepyramine maleate 是第一代抗组胺剂，为 histamine H1 受体拮抗剂，对 H1，H2 和 H3 受体的 Kd 值分别为 0.8 nM，5200 nM 和 >3000 nM，对 H1 受体的 pKd 值为 9.4。
研究领域：GPCR/G Protein | Neuronal Signaling | Immunology/Inflammation
作用靶点：Histamine Receptor
In Vitro: Mepyramine maleate is an antagonist of histamine H1 receptor, with Kds of 0.8 nM, 5200 nM and >3000 nM for H1, H2, and H3 receptor, respectively, and a pKd of 9.4 for H1 receptor. Mepyramine binds to the H1 receptor with different Kds in Guinea pig brain (0.8 nM), rat brain (9.1 nM) and DDT1-MF-2 and BC3H1 cell (276 nM). Mepyramine decreases the InsP levels in CHO-gpH1 cells, with log EC50 of -7.94 ± 0.11, and reduces the the maximal response to ATP in CHO-gpH1 cells.
In Vivo: Mepyramine obviously decreases the second phase of nociceptive response via i.p at 10 and 20 mg/kg, but shows no significant effect at 5 mg/kg in rats.
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文献和实验Characterization of Histaminergic Receptors
Table of Contents Strategic Planning Basic Protocol 1: Measurement of [3H]Mepyramine Binding to Cloned Human H1 Receptors Alternate Protocol 1: Measurement
sodium maleate pH 5.2 (3 x 5'). 8). en bloc stain in 1% uranyl acetate in maleate buffer pH 5.2 (1 hr RT). Using uranyl acetate at low pH will improve membrane contrast. Analternative contrasting method, which adds even more membrane contrast
糖液500ml稀释后缓慢滴入。 马来酸麦角新碱（ergometrine maleate）口服，0.2～0.5mg/次。肌内注射，0.2～0.5mg/次，必要时半小时后重复一次。静脉滴注0.2mg以5%葡萄糖溶液稀释后应用。极量：肌内或静脉注射，0.5mg/次，1mg/日。 酒石酸麦角胺（ergotamine tartrate）口服1mg/次。皮下或肌内注射，0.25mg/次。 麦角胺咖啡因片 每片含酒石酸麦角胺1mg，咖啡因100mg。偏头痛发作时即口服半片至1片半；如无效，可于
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