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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
MK-677; MK-0677
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
159752-10-0
- 规格：
10 mM * 1 mL/5 mg/10 mg/50 mg/100 mg/200 mg/500 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥770.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥500.0 |
| 规格： | 10 mg | 产品价格： | ￥700.0 |
| 规格： | 50 mg | 产品价格： | ￥1320.0 |
| 规格： | 100 mg | 产品价格： | ￥1800.0 |
| 规格： | 200 mg | 产品价格： | ￥2340.0 |
| 规格： | 500 mg | 产品价格： | ￥4320.0 |
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Ibutamoren Mesylate
CAS No. : 159752-10-0
MCE 国际站：Ibutamoren Mesylate
产品活性：Ibutamoren Mesylate (MK-677) 是一种有效的，非肽段类生长激素促分泌素受体 (GHSR) 激动剂。Ibutamoren Mesylate 是一种有效的，具有口服活性的生长激素 (GH) 促分泌素。
研究领域：GPCR/G Protein
作用靶点：GHSR
In Vivo: Ibutamoren mesylate (5 mg/kg/day) results in a statistically significant increases body weight gain and increases serum IGF-1 and GH levels in dogs. Ibutamoren mesylate results in no significant increase in CSF IGF-1 or GH levels on days 7 or 15 of the study. Pretreating mice with GH blocks activation of these neurons by Ibutamoren mesylate (50 μg, i.p.). In the knockout mice, both GH and octreotide fail to inhibit Ibutamoren mesylate activation of arcuate neurons. Chronic oral administration of Ibutamoren mesylate is associated with significant increases in GH and IGF-I levels that are maintained for the duration of the treatment. The GH profile following Ibutamoren mesylate administration consists of episodic increases above control. Ibutamoren mesylate significantly increases peak GH concentrations after oral administration. Ibutamoren mesylate is a potent GH secretagogue that induces an immediate, large, long lasting increase in GH levels when administered orally or i.v.
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