JNJ-46778212,1363281-27-9

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JNJ-46778212

CAS No. : 1363281-27-9

MCE 国际站：JNJ-46778212

产品活性：JNJ-46778212 (VU 0409551) 是 mGlu5 正变构调节剂，EC₅₀ 值为260 nM。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：mGluR

In Vivo: In oral brain/plasma studies, JNJ-46778212 displays excellent CNS penetration. JNJ-46778212 enhances NMDAR function and rescues long-term potentiation in hippocampal slices obtained from SR^−/− mice. The administration of JNJ-46778212 to SR^−/− mice reverses their deficits in several neuroplasticity signaling pathways and improves their contextual fear memory.

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