Candesartan Cilexetil坎地沙坦酯,145

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Candesartan Cilexetil

CAS No. : 145040-37-5

MCE 国际站：Candesartan Cilexetil

产品活性：Candesartan Cilexetil (TCV-116) 是一种血管紧张素 II 受体 (angiotensin II receptor) 抑制剂，Candesartan Cilexetil 具有改善肺纤维化，抗病毒和皮肤创面愈合作用，可用于高血压的研究。

研究领域：GPCR/G Protein  |  Apoptosis

作用靶点：Angiotensin Receptor  |  Apoptosis

In Vitro: Candesartan Cilexetil (0.1-10 μM, 24 h) exhibits antiviral effects against ZIKV in HUVEC cells, HEK293T cells.

In Vivo: Candesartan Cilexetil (5 mg/kg, Oral gavage, once a day for 7 weeks) ameliorates myocardial remodeling and heart failure in Dahl salt-sensitive (DS) rats fed a high-salt diet.
Candesartan Cilexetil (1-10 mg/kg, Oral, once a day for 15 days) has an effect of skin wound healing in rats.
Candesartan Cilexetil (1-10 mg/kg, Administered through a stomach tube, once a day for 4-12 weeks) inhibits the increase in blood pressure in spontaneously hypertensive rats.
Candesartan Cilexetil (10 mg/kg, Oral, supplemented in drinking water, for 2-23 days) inhibits the synthesis of TGF-b1 and ameliorates the pulmonary fibrosis in bleomycin (HY-108345) induced pulmonary fibrosis model rats.

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