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- 详细信息
- 技术资料
- 保存条件:
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名:
RNH-6270
- 库存:
货期:1-2天
- 供应商:
MedChemExpress LLC
- CAS号:
144689-24-7
- 规格:
10 mM * 1 mL/25 mg/50 mg/100 mg
| 规格: | 10 mM * 1 mL | 产品价格: | ¥550.0 |
|---|---|---|---|
| 规格: | 25 mg | 产品价格: | ¥500.0 |
| 规格: | 50 mg | 产品价格: | ¥800.0 |
| 规格: | 100 mg | 产品价格: | ¥1300.0 |
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Olmesartan
CAS No. : 144689-24-7
MCE 国际站:Olmesartan
产品活性:Olmesartan (RNH-6270) 是血管紧张素II受体 (AT1R) 拮抗剂,常用于高血压的相关研究。
研究领域:GPCR/G Protein
作用靶点:Angiotensin Receptor
In Vitro: Olmesartan (0.7-5 mM; 24, 48 and 72 h) inhibits the growth of HeLa cells as a concentration- and time-dependent mode.
In Vivo: Repeated dosing of olmesartan (1 mg/kg, 2 mg/kg, p.o.) dose-dependently decreases mean arterial blood pressure (MAP) in SHR without significant influence on body weight and food intake during 10 weeks. Olmesartan (5 mg/kg/d, p.o.) and Hyd treatments lower systolic blood pressure to the same degree in mice. Olmesartan treatment inhibits cardiac hypertrophy, evaluated by echocardiography, heart weight, cross-sectional area of cardiomyocytes, and gene expression. Olmesartan treatment reverses decreased gene expressions of ACE2 and Mas receptor of Ren-Tg mice and inhibits enhanced NADPH oxidase (Nox)4 expression and reactive oxygen species.
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