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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
Powder: -20°C, 3 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名:
(S)-FTY720P; (S)-FTY720 phosphate
- 库存:
货期:1-2天
- 供应商:
MedChemExpress LLC
- CAS号:
402616-26-6
- 规格:
1 mg/5 mg
| 规格: | 1 mg | 产品价格: | ¥2080.0 |
|---|---|---|---|
| 规格: | 5 mg | 产品价格: | ¥5200.0 |
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FTY720 (S)-Phosphate
CAS No. : 402616-26-6
MCE 国际站:FTY720 (S)-Phosphate
产品活性:FTY720 (S)-Phosphate 是一种 S1P 受体 1 (S1PR1) 激动剂,可以用于急性肺损伤等急性炎症的研究。
研究领域:GPCR/G Protein
作用靶点:LPL Receptor
In Vitro: FTY720 (S)-Phosphate is an agonist of S1PR1. FTY720 (S)-Phosphate (Tys, 1 µM) maintains S1PR1 protein expression, enhances the human pulmonary artery endothelial cells barrier via S1PR1, but shows no effect on inducing ubiquitination of S1PR1. FTY720 (S)-Phosphate (0.01-50 µM) also reduces β-arrestin recruitment to S1PR1.
In Vivo: FTY720 (S)-Phosphate (0.5 mg/kg, i.p.) preserves S1PR1 expression in mouse lungs, is protective in bleomycin-induced acute lung injury (ALI) and attenuates lung tissue leukocyte infiltration in bleomycin-injured mice.
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