Tipelukast,125961-82-2

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Tipelukast

CAS No. : 125961-82-2

MCE 国际站：Tipelukast

产品活性：Tipelukast (KCA 757) 是一种白三烯受体 (leukotriene receptor) 拮抗剂，是一种可口服的抗炎剂，同时可用于哮喘的研究。

研究领域：GPCR/G Protein

作用靶点：Leukotriene Receptor

In Vitro: Tipelukast inhibits the binding of [³H] LTD4 to the LTD4 receptors on pul-monary cell membrane of guinea-pigs (IC₅₀ = 2.3 μmol).

In Vivo: Fiftheen min after an aerosolized antigen challenge, and UNDW inhaled 5 min later into the guinea pigs, Tipelukast significantly alters the UNDW-induced bronchoconstriction. Tipelukast (1 and 5 mg/kg) administered intravenously 15 min after antigen challenge reduces the propranolol-induced bronchoconstriction (PIB) in a dose-dependent manner in guinea-pigs.

相关产品：MK-571 sodium  |  Montelukast sodium  |  MK-886  |  Zafirlukast  |  Leukotriene B4  |  Pranlukast  |  Tryptanthrin  |  Fiboflapon  |  Olsalazine Disodium  |  CP-105696  |  LY255283  |  BIIL-260 hydrochloride  |  Nedocromil  |  Gemilukast  |  Darbufelone mesylate  |  Etalocib  |  Veliflapon  |  5-O-Demethylnobiletin  |  LY223982  |  11-​Keto-​beta-​boswellic acid  |  (S)-Verapamil hydrochloride  |  12S-HHT  |  KP496  |  Quinotolast sodium  |  (Rac)-HAMI 3379  |  Amelubant  |  AS-35

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds