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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
GSK561679
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
885220-61-1
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1870.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥650.0 |
| 规格： | 5 mg | 产品价格： | ￥1700.0 |
| 规格： | 10 mg | 产品价格： | ￥3000.0 |
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Verucerfont
CAS No. : 885220-61-1
MCE 国际站：Verucerfont
产品活性：Verucerfont 是促肾上腺皮质激素释放因子受体 1 (CRF1) 的拮抗剂，对于 CRF1，CRF2 和 CRF-BP 的 IC50 值分别为 6.1，>1000 和 >1000 nM。
研究领域：GPCR/G Protein
作用靶点：CRFR
In Vivo: Post hoc analysis shows that the prototypic non-peptide CRF1 receptor antagonist NBI30775 (R121919) and Verucerfont are both significantly different from vehicle, CP-316 311, and pexacerfont (P<0.001 for all comparisons collapse across time-points); the latter three treatments in turn do not differ from each other. A differential effect of treatments over time is also shown by a significant treatment×time interaction (F[20,140]=6.4, P<0.001). Accordingly, detailed Post hoc analysis shows that both NBI30775 and Verucerfont inhibit ACTH release throughout the following 6 h of measurement (P<0.001 vs vehicle at each time-point, and vs the respective pretreatment baseline).
相关产品：Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Clinical Compound Library | Drug Repurposing Compound Library | Endocrinology Compound Library | Orally Active Compound Library | Targeted Diversity Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | R121919 | Antalarmin hydrochloride | Cortagine | NBI-27914 | Antisauvagine-30 TFA | CRF, bovine TFA | Pexacerfont | Urocortin, human | CP 376395 | DMP 696 | Urocortin III, mouse TFA | α-Helical CRF(9-41) | Stressin I TFA | [DPro5] Corticotropin Releasing Factor, human, rat TFA | NVS-CRF38 | Sauvagine TFA | Tildacerfont | Urocortin, rat | Urotensin I | (D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) | (Tyr0)-Urocortin, rat | a-Helical Corticotropin Releasing Factor (12-41) | a-Helical Corticotropin Releasing Factor (9-41) | BMS-665053
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