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货期：电询
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MedChemExpress LLC
- CAS号：
1217756-94-9
- 规格：
电询
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LY 344864 hydrochloride
CAS No. : 1217756-94-9
MCE 国际站：LY 344864 hydrochloride
产品活性：LY 344864 hydrochloride 是一种选择性的、具有口服活性的 5-HT1F receptor 激动剂，Ki 为 6 nM。LY 344864 hydrochloride 是一种完全激动剂，产生的效果与血清素本身的量级相似。 LY 344864 hydrochloride 在一定程度上可以通过血脑屏障。
研究领域：GPCR/G Protein | Neuronal Signaling
作用靶点：5-HT Receptor | Adrenergic Receptor
In Vitro: LY 344864 binds to human 5-HT1F, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT3A, 5-HT2B, 5-HT2C, 5-HT7, rat α1-adrenergic, rat α2-adrenergic receptors with Kis of 0.006, 0.530, 0.549, 0.575, 1.415, 3.935, 1.695, 3.499, 4.851, 5.06 and 3.69 μM, respectively.
LY 344864 is a inducer of mitochondrial biogenesis.
In Vivo: LY 344864 (0-10 ng/kg; p.o. or i.v.; once) inhibits neurogenic dural inflammation in rat migraine pain model.
LY 344864 (1 mg/kg; i.v.; once) can cross the blood brain barrier to some extent in rats.
LY 344864 (2 mg/kg; i.p.; daily for 14 days) attenuates dopaminergic neuron loss and improved behavioral endpoints in a Parkinson’s disease mouse model.
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文献和实验Conjugation of 5′‐Functionalized Oligodeoxyribonucleotides with Properly Functionalized Ligands
, base (i.e., thymine, cytosine, adenine, or guanine); EDC, 1‐[3‐(dimethylamino)propyl]‐3‐ethylcarbodiimide hydrochloride; LY, Lucifer Yellow (R). View Image
/ ampoule 卷曲霉素冻干粉 标准品 920 IU / mg, Approximately 80mg of capreomycin sulfate. 人癌胚抗原(CEA)冻干粉 标准品 100 IU / ampoule 氯四环素冻干粉 标准品 1,000 IU / mg, Approximately 75 mg of chlortetracycline hydrochloride. 羊霍乱抗毒素冻干粉 标准品 2,200 IU / ampoule 第四页 霍乱疫苗冻干粉(Inaba) 标准
, Approximately 80mg of capreomycin sulfate. 人癌胚抗原(CEA)冻干粉 标准品 100 IU / ampoule 氯四环素冻干粉 标准品 1,000 IU / mg, Approximately 75 mg of chlortetracycline hydrochloride. 羊霍乱抗毒素冻干粉 标准品 2,200 IU / ampoule 第四页 霍乱疫苗冻干粉(Inaba) 标准品 40,000,000,000 organisms /ampoule. 霍乱疫苗冻干
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