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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1173154-32-9
- 规格：
5 mg/10 mg/25 mg
| 规格： | 5 mg | 产品价格： | ￥1200.0 |
|---|---|---|---|
| 规格： | 10 mg | 产品价格： | ￥2000.0 |
| 规格： | 25 mg | 产品价格： | ￥4400.0 |
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ALB-127158(a)
CAS No. : 1173154-32-9
MCE 国际站：ALB-127158(a)
产品活性：ALB-127158(a) 是一种有效的选择性黑色素浓缩激素 1 (MCH1) 受体拮抗剂。
研究领域：GPCR/G Protein | Neuronal Signaling
作用靶点：MCHR1 (GPR24)
In Vitro: ALB-127158(a) has high affinity for the MCH1 receptor (7 nM) with good selectivity over a range of other G-protein coupled receptors (GPCRs), ion channels and transporters, including the MCH2 receptor. In vitro functional assays confirmed that ALB-127158(a) is a potent and selective MCH1 receptor antagonist.
In Vivo: In a mouse diet induced obesity (DIO) model, ALB-127158(a) produces a significant sustained decrease in body weight and food intake in the range of 5-15 mg/kg bid. The weight reduction is predominantly due to a decrease in fat content. In high fat diet (HFD) rats, ALB-127158(a) produces significant weight loss and food reduction at doses as low as 1.25 mg/kg po. Doses > 1.25 mg/kg po produces weight loss > 6%, maximal weight loss of about 10% in rats is observed at 10 mg/kg. Following single and multiple oral administration of ALB-127158(a), ALB-127158(a) is rapidly absorbed (median tmax attains between 1 and 3 h post dose in lean and overweight/obese subjects) with a trend to decrease over dose suggesting a slower absorption rate of ALB-127158(a) at lower doses. After single doses, ALB-127158(a) has a mean half-life (t1/2) of 18 to 21 h. Slightly longer mean t1/2 estimates of approximately 26 h are obtained following multiple dosing in overweight/obese subjects; steady-state plasma ALB-127158(a) is attained within 6 to 8 days of dosing.
相关产品：Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Neuronal Signaling Compound Library | Endocrinology Compound Library | Anti-Obesity Compound Library | Targeted Diversity Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Inhibitors Library | SNAP 94847 hydrochloride | Melanin Concentrating Hormone, salmon TFA | MCH(human, mouse, rat) TFA | AZD1979 | [Ala17]-MCH | Ethyl linolenate | GW-803430 | MCH-1 antagonist 1 | MCHR1 antagonist 2 | TC-MCH 7c | (Phe13,Tyr19)-MCH (human, mouse, rat) | Ac-hMCH(6-16)-NH2 | AMG-076 | ATC0175 | BMS-814580 | hMCH-1R antagonist 1 | MCHR1 antagonist 3 | Neuropeptide EI, rat | BMS-819881 | MCHR1 antagonist 1 | NGD-4715 | SB-568849
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文献和实验35.32±6.35 482 ALP U/L 80.28±20.38
/L) TT(s) 滤前 13.32±0.64 1.109±0.05 35.26±22.63 2.204±0.57 16.45±1.64 滤后 13.86±0.64 1.155±0.05 83.31±27.63 2.333±0.57 18.29±1.64 t值 2.5730 2.8383 6.7138 1.2712 3.5452 p值 0.05 续表：新鲜冰冻血浆白细胞过滤前后血浆凝血因子及血浆蛋白的变化 FⅦ% FⅧ% FⅨ% TP(g/L) ALB(g/L) 滤前 94.08
结果的项目主要有：LDH、K、Hb、ACP；有值得注意的影响的项目主要有：Fe、ALT、T4；有轻微影响或不太受影响的项目主要有：TP、ALB�ALP、AST�TBiL�WBC、APTT、TT�Cr、Urea、UA、P、Mg、Ca。 4.标本送出及签收 临床人员从病人采集标本并将标本从临床运送到实验室及实验室人员接受临床标本，均应按标准化要求进行，并且一定要做到认真核对。包括标本来源、标本属性、检查项目、标本采集和运送是否合乎要求等，标本送出人员和标本接受人员都要做认真的记录并签字
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