L 888607,860033-06-3

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L 888607

CAS No. : 860033-06-3

MCE 国际站：L 888607

产品活性：L 888607 是一种有效稳定的选择性 CRTH2 激动剂，具有口服活性。L 888607 对人 CRTH2 受体具有高亲和力，K_i 值为 4 nM。L 888607 可用于多种生理事件和代谢的研究。

研究领域：GPCR/G Protein

作用靶点：Prostaglandin Receptor

In Vitro: L 888607 has high affinity for the human CRTH2 receptor with a K_i value of 4 nM.
L 888607 has some affinity for the human DP receptor with a K_i value of 211 nM.
L 888607 displays a relatively high selectivity for CRTH2 receptor.
L 888607 has agonistic activity on recombinant and endogenously expressed CRTH2 receptor with an EC₅₀ value of 0.4 nM.
L 888607(100 nM, 20 min) stimulates eosinophil chemotaxis.

In Vivo: L 888607 (i.v., 5 mg/kg, single or oral, 20 mg/kg, single) shows relative stability in vivo.

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