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- MedChemExpress(MCE)
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- 2025年07月13日
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- 详细信息
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1064662-40-3
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥3631.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1363.0 |
| 规格： | 5 mg | 产品价格： | ￥3000.0 |
| 规格： | 10 mg | 产品价格： | ￥5700.0 |
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SNT-207707
CAS No. : 1064662-40-3
MCE 国际站：SNT-207707
产品活性：SNT-207707是一种有效，选择性，有口服活性的黑素皮质素受体 (melanocortin MC-4) 拮抗剂，IC50 值为8 nM (结合) 和5 nM (功能)。
研究领域：GPCR/G Protein | Neuronal Signaling
作用靶点：Melanocortin Receptor
In Vitro: SNT-207707 binds to the MC-4 receptor with an affinity of 8 nM and shows a more than 200-fold selectivity vs. MC-3 and MC-5. SNT207858 is a 22 nM MC-4 antagonist with a 170-fold selectivity vs. MC-3 and a 40-fold selectivity versus MC-5.
In Vivo: Single subcutaneous injection of 20 mg/kg of SNT-207707 distinctly increases food intake of the mice. Once daily oral administration of both compounds SNT207858 and SNT-207707 starting the day after tumor implantation significantly reduces the tumor induced weight loss.
相关产品：Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Neuronal Signaling Compound Library | Anti-Cancer Compound Library | CNS-Penetrant Compound Library | Endocrinology Compound Library | Orally Active Compound Library | Targeted Diversity Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Inhibitors Library | α-MSH | SHU 9119 | Melanotan I | Bremelanotide Acetate | Adrenocorticotropic Hormone (ACTH) (1-39), rat TFA | BMS-470539 dihydrochloride | THIQ | Nonapeptide-1 acetate salt | JNJ-10229570 | PF-00446687 | HS024 TFA | β-Melanocyte Stimulating Hormone (MSH), human TFA | ACTH (1-17) (TFA) | RO27-3225 TFA | ACTH (11-24) | Adrenocorticotropic Hormone (ACTH) (1-39), human(TFA) | HS014 TFA | MK-0493 | SNT-207858 free base | Dersimelagon | ML00253764 | MSG606 | PG-931 | γ-1-Melanocyte Stimulating Hormone (MSH), amide | Fenoprofen | [D-Trp8]-γ-MSH | γ1-MSH
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