HT-2157,303149-14-6

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

HT-2157

CAS No. : 303149-14-6

MCE 国际站：HT-2157

产品活性：HT-2157(SNAP 37889) 是一种选择性的高亲和力甘丙肽-3 受体 (Gal₃) 竞争性拮抗剂。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Neuropeptide Y Receptor

In Vitro: HT-2157 (SNAP 37889) binds with high affinity to membranes from transiently transfected LMTK^- cells expressing the human Gal₃ receptor (K_i=17.44±0.01 nM; n>100) and is highly selective for Gal₃ over the Gal₁ and Gal₂ subtypes (K_i>10,000 nM for each subtype; n=46 of each subtype). When tested for the antagonism of galanin-evoked inhibition of adenylyl cyclase, HT-2157 (0.1-10 μM) produces concentration-dependent rightward shifts of the concentration-effect curve to galanin.

In Vivo: The galanin-3 receptor antagonist, HT-2157 (SNAP 37889), reduces operant responding for ethanol in alcohol-preferring rats. The novel selective GALR3 antagonist, HT-2157, to reduce anxiety-like behaviour and voluntary ethanol consumption in the iP (alcohol-preferring) rat. Male iP rats treated with HT-2157 at a dose of 30 mg/kg (i.p.) do not show altered locomotor activity or changes in anxiety-like behaviour in the elevated plus maze or light-dark paradigms. Treatment with HT-2157 (30 mg/kg, i.p.) reduces operant responding for solutions containing ethanol, sucrose and saccharin. Collectively, results from the current study shows that HT-2157 (30 mg/kg, i.p.) is effective in reducing operant responding for ethanol.

相关产品：Drug Repurposing Compound Library Plus  |  Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  Neuronal Signaling Compound Library  |  Clinical Compound Library  |  Drug Repurposing Compound Library  |  Endocrinology Compound Library  |  Anti-COVID-19 Compound Library  |  Neurotransmitter Receptor Compound Library  |  Anti-Obesity Compound Library  |  Targeted Diversity Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  Highly Selective Inhibitors Library  |  BIBO3304 TFA  |  Galanin (1-30), human  |  SHA 68  |  MK-0557  |  Neuropeptide Y (human) (TFA)  |  Spexin  |  BIBP3226 TFA  |  JNJ-31020028  |  Peptide YY (PYY) (3-36), porcine TFA  |  CGP71683 hydrochloride  |  Galanin Receptor Ligand M35  |  BMS-193885  |  RF9  |  L 152804  |  Neuropeptide Y (3-36) (human, rat)  |  RFRP-3(human)  |  [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA  |  BIIE-0246  |  Pancreatic Polypeptide, human  |  Velneperit  |  CYM 9484  |  Galnon TFA  |  RFRP-1(human)  |  [Leu31,Pro34]-Neuropeptide Y (porcine)  |  CART(55-102)(human)  |  M617 TFA  |  Neuropeptide S(Mouse)  |  Galanin (1-16), mouse, porcine, rat TFA

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds