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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
ML130; CID-1088438
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
799264-47-4
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥550.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥500.0 |
| 规格： | 10 mg | 产品价格： | ￥700.0 |
| 规格： | 25 mg | 产品价格： | ￥1250.0 |
| 规格： | 50 mg | 产品价格： | ￥2000.0 |
| 规格： | 100 mg | 产品价格： | ￥3500.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Nodinitib-1
CAS No. : 799264-47-4
MCE 国际站：Nodinitib-1
产品活性：Nodinitib-1 (ML130;CID-1088438)是NOD1抑制剂，IC50值为0.56 μM。
作用靶点：NOD-like Receptor (NLR)
In Vitro: Nodinitib-1 selectively inhibits IL-8 production induced by NOD1 ligand. Nodinitib-1 also inhibits γ-tri-DAP-induced expression of the prototypical NF-κB target gene IκBα at the mRNA level. Nodinitib-1 inhibits γ-tri-DAP-dependent activation of NF-κB (IκBα phosphorylation and degradation) and MAPK (p38 phosphorylation) signalings, without affecting Akt survival pathway. Nodinitib-1 selectively inhibits responses of primary dendritic cells to NOD1 ligand. Nodinitib-1 reduces cell surface expression of co-stimulatory molecules CD83, CD86 and HLA-DR and also inhibits expression of IL-1β, IL-6 and TNFα elicited by γ-tri-DAP (but not by LPS), without causing cytoxicity. Nodinitib-1 is identified as NOD1-selective molecules from an HTS campaign involving ~290,000 compounds. Nodinitib-1 inhibits γ-tri-DAP-stimulated luciferase production in HEK 293T cells, which has endogenous NOD1 levels at submicromolar concentration as determined in a NF-κB-linked reporter assay.
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