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- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
RG 7421; MEK inhibitor 1
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1168091-68-6
- 规格：
10 mM * 1 mL/1 mg/2 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1405.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥666.0 |
| 规格： | 2 mg | 产品价格： | ￥950.0 |
| 规格： | 5 mg | 产品价格： | ￥1400.0 |
| 规格： | 10 mg | 产品价格： | ￥2248.0 |
| 规格： | 25 mg | 产品价格： | ￥3259.0 |
| 规格： | 50 mg | 产品价格： | ￥4400.0 |
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GDC-0623
CAS No. : 1168091-68-6
MCE 国际站：GDC-0623
产品活性：GDC-0623 (RG 7421) 是一种有效的，ATP 竞争性的 MEK1 抑制剂，Ki值为 0.13 nM，对 HCT116 细胞中 KRAS (G13D)的 EC50 值为 42 nM，而对 A375 细胞中 BRAFV600E的 EC50 值为 7 nM。
研究领域：MAPK/ERK Pathway | Apoptosis
In Vitro: GDC-0623 (RG 7421) and G-573 are able to prevent MEK phosphorylation by CRAF in vitro, and able to block MEK phosphorylation by BRAF(V600E). GDC-0623 (RG 7421) is potent, ATP-uncompetitive inhibitors of MEK1 but shows distinct shifts in cellular activity compared with the other two inhibitors, only 6-fold half-maximum effective concentration (EC50) decreases.
In Vivo: GDC-0623 (RG 7421) (40 mg/kg, p.o.) shows percent tumour growth inhibition (%TGI) in MiaPaCa-2 xenograft model. GDC-0623 (RG 7421) and G-573 show superior antitumour activity compared to GDC-0623 (RG 7421) in all three KRAS models.
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文献和实验9ZttBbJQ8joJWDztq26nnX7ayYN9mjCn0yV7ZDph9jDDz9s3/6Xf7HNG9bbeWfPsyeeeMq14xDkgggycwdLMlPJYQISQ0TgTUYgkuQ3GfBYXEQgIhARiAjsvwg0RXqZfQYxnTXjOHvw/gfsEZlHVFl9T5R1hzxKfOpTn9Jsu7oNaS/65LmG0uAfGBvc6UfOsB/95GprbWsXYa7bPbI1Pu7oY6xPGuRTTjvdvviXf23jxo2zYcOG2nhpYq/68Y
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