DMX-5804,2306178-56-1

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DMX-5804

CAS No. : 2306178-56-1

MCE 国际站：DMX-5804

产品活性：DMX-5804 是一种有效、可口服、选择性的 MAP4K4 抑制剂，对人 MAP4K4 的 IC₅₀ 值为 3 nM，pIC₅₀ 值为 8.55；对 MINK1/MAP4K6 (pIC₅₀，8.18) 和 TNIK/MAP4K7 (pIC₅₀，7.96) 的作用相对较弱。DMX-5804 能够增强心肌细胞存活率，减少小鼠的缺血再灌注损伤。

研究领域：MAPK/ERK Pathway

作用靶点：MAP4K

In Vitro: DMX-5804 exhibits great selectivity at MAP4K4 over other kinases, such as GCK/MAP4K2 (pIC₅₀, 6.50), GLK/MAP4K3 (pIC₅₀, 4.95), KHS/MAP4K5 (pIC₅₀, 6.36), ABL1 (pIC₅₀, 5.80), Aurora B (pIC₅₀, 5.49), FLT3 (pIC₅₀, 5.31), GSK3β (pIC₅₀, 4.66), MLK1/MAP3K9 (pIC₅₀, 7.19), MLK3/MAP3K11 (pIC₅₀, 6.99), NUAK (pIC₅₀, 6.88) and VEGFR (pIC₅₀, 5.72).

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