- ￥1173 - 4480
- MedChemExpress(MCE)
- 美国
- HY-111483
- 2025年12月05日
企业认证
相关产品推荐更多 >
![3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanamide (Standard)DIC脲结构杂质 (标准品),1675248-19-7](https://img1.dxycdn.com/p/s14/2025/1205/714/4872850177416686991.jpg!wh200)
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
AZD0364
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2097416-76-5
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥3046.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1173.0 |
| 规格： | 5 mg | 产品价格： | ￥2800.0 |
| 规格： | 10 mg | 产品价格： | ￥4480.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Tizaterkib
CAS No. : 2097416-76-5
MCE 国际站：Tizaterkib
产品活性：Tizaterkib (AZD0364) 是一种有效的选择性 ERK2 抑制剂，IC50 为 0.6 nM。详细信息请参考专利文献 WO2017080979A1 中的化合物 example 18。
研究领域：MAPK/ERK Pathway | Stem Cell/Wnt
作用靶点：ERK
In Vitro: Tizaterkib is measured in the ERK2 mass spectrometry and A375 phospho-p90RSK assays with IC50s of 0.6 nM and 5.7 nM, respectively. Tizaterkib can inhibit the growth of a panel of cancer cell lines (A549, H2122, H2009, and Calu6 cell lines) with KRAS mutations as a monotherapy and this effect is synergistically enhanced by treatment with Selumetinib.
In Vivo: Tumor growth inhibition by Tizaterkib ethanesulfonic acid (Example 18a) in combination with MEK inhibitor Selumetinib is measured. Studies are performed in the A549 xenograft model. Selumetinib is dosed twice daily (BiD) 8 hours apart and Tizaterkib ethanesulfonic acid is dosed once daily (QD) 4 hours after the first Selumetinib dose. Both compounds are dosed continuously for 3 weeks. Both vehicles are dosed in the vehicle group. Both Selumetinib and Tizaterkib ethanesulfonic acid reduce tumor growth relative to vehicle only control. The combination of Selumetinib and Tizaterkib ethanesulfonic acid results in a reduction in tumor growth.
相关产品：Bioactive Compound Library Plus | PD98059 | Yoda 1 | SCH772984 | TBHQ | Tauroursodeoxycholate | Ulixertinib | Honokiol | Astragaloside IV | Piperlongumine | Ravoxertinib | Temuterkib | C16-PAF | Lidocaine | FR 180204 | BIX02189 | XMD8-92 | MK-8353 | 6-OAU | Patritumab | trans-Zeatin | SEW2871 | Urolithin B | VX-11e | ASN007 | Pamoic acid | Pachymic acid | AG126 | Lysophosphatidylcholines
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验动物种类 肠 道 长 度 单位 全长 小肠 盲肠 大肠 狗 m 2.2-5
中性粒细胞（ GRAN ） 绝对值：（ 18-64 ） ×109/L 百分率 : 46.0-76.5% 中性粒细胞（ GRAN ） 绝对值：（ 18-64 ） ×109/L 百分率 : 46.0-76
Fluorescence In Situ Hybridization
mixture at 76ºC, 5 min Incubate at 37ºC for 30-60min, competition Optional: Co-denaturation Apply probes to slide and denature at 80ºC on a heat block for 2-5 minutes HYBRIDIZATION Apply probes to dried slide Seal with rubber cement
技术资料暂无技术资料 索取技术资料
