MK-8353,1184173-73-6

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

MK-8353

CAS No. : 1184173-73-6

MCE 国际站：MK-8353

产品活性：MK-8353 (SCH900353) 是一种有效的，选择性的，可口服的 ERK1/2 抑制剂，IC₅₀ 值分别为 23.0 nM 和 8.8 nM；MK-8353 具有抗肿瘤活性。

研究领域：MAPK/ERK Pathway  |  Stem Cell/Wnt

作用靶点：ERK

In Vitro: MK-8353 is a potent, selective and orally available ERK1/2 inhibitor, with IC₅₀s of 23.0 nM and 8.8 nM, respectively; MK-8353 has antitumor activity. MK-8353 only at 1 μM shows >50% inhibition on 3 kinases (CLK2, FLT4, and Aurora B), and no other kinases tested are inhibited by >35% at 0.1 μM. MK-8353 also shows potent antitumor activity against various cancer cell lines, such Malme-3M cells (Melanoma), Colo-205 cells (Colon), NCI-H292 cells (Lung), A-549 cells (NSCLC), 8505C cells (Thyroid), SW-626 cells (Ovarian), with EC₅₀s of 21 nM, 19 nM, 130 nM, 230 nM, 210 nM, 108 nM.

In Vivo: MK-8353 (60 mg/kg, p.o., bid (twice daily)) causes at least 50% tumor growth inhibition or regression in 83% of the animal models bearing different tumor cells, including LOX, Colo-205, MIA PaCa-2, and Calu-6 cells.

相关产品：Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  Kinase Inhibitor Library  |  MAPK Compound Library  |  Stem Cell Signaling Compound Library  |  Anti-Cancer Compound Library  |  Clinical Compound Library  |  Anti-Aging Compound Library  |  Reprogramming Compound Library  |  Oxygen Sensing Compound Library  |  Orally Active Compound Library  |  Glutamine Metabolism Compound Library  |  Anti-Lung Cancer Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Obesity Compound Library  |  Angiogenesis-Related Compound Library  |  Anti-Liver Cancer Compound Library   |  Anti-Colorectal Cancer Compound Library   |  Anti-Prostate Cancer Compound Library  |  Anti-Pulmonary Fibrosis Compound Library  |  Cancer Stem Cells Compound Library  |  Heterocyclic Compound Library  |  Pain-Related Compound Library  |  Highly Selective Inhibitors Library  |  Serine/Threonine Kinase Inhibitor Library  |  PD98059  |  Yoda 1  |  SCH772984  |  TBHQ  |  Tauroursodeoxycholate  |  Ulixertinib  |  Honokiol  |  Astragaloside IV  |  Piperlongumine  |  Ravoxertinib  |  Temuterkib  |  C16-PAF  |  Lidocaine  |  FR 180204  |  BIX02189  |  XMD8-92  |  6-OAU  |  Patritumab  |  trans-Zeatin  |  SEW​2871  |  Urolithin B  |  VX-11e  |  ASN007  |  Pamoic acid  |  Pachymic acid  |  AG126  |  Lysophosphatidylcholines  |  LM22B-10

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds