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- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
92439-20-8
- 规格：
10 mM * 1 mL/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥660.0 |
|---|---|---|---|
| 规格： | 50 mg | 产品价格： | ￥600.0 |
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6,2'-Dihydroxyflavone
CAS No. : 92439-20-8
MCE 国际站：6,2'-Dihydroxyflavone
产品活性：6,2'-Dihydroxyflavone 是一个新型的 GABAA 受体拮抗剂。
研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling
作用靶点：GABA Receptor
In Vitro: 6,2'-Dihydroxyflavone is a novel antagonist of GABAA receptor. 6,2'-Dihydroxyflavone inhibits [3H]-flunitrazepam binding to the rat cerebral cortex membranes with a Ki of 37.2±4.5 nM. The current elicited with the EC50 concentration of GABA is decreased to 73.6±1.9% of control by co-application of 5 μM 6,2'-Dihydroxyflavone (n=5), compare to a decrease to 65.9±3.0% by 1 μM FG-7142 (n=5). The EC50 for GABA dose response increases from 47.6 to 59.7 μM upon co-application of 5 μM 6,2'-Dihydroxyflavone, and the maximal GABA-current is decreased.
In Vivo: 6,2'-Dihydroxyflavone-treated mice exhibit significant differences from control mice with respect to the percentage of open arms entries [F(4,73)=8.01, P<0.0001] and the percentage of time spent in open arms [F (4,73)=5.19, P<0.002], but not the number of entries to closed arms [F(4,73)= 0.79,P=0.54]. The post-hoc NewmaneKeuls’ tests confirm that 6,2'-Dihydroxyflavone significantly decreases the percentage of open arm entries and time spent in open arms at the doses of 8 and 16 mg/kg. 6,2'-Dihydroxyflavone treatment similarly increases step-through latency [F(4,75)=4.71, P<0.002], suggesting enhanced cognitive performance.
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