Orphenadrine盐酸奥芬那君,341-69-5

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Orphenadrine hydrochloride

CAS No. : 341-69-5

MCE 国际站：Orphenadrine hydrochloride

产品活性：Orphenadrine hydrochloride 是一种口服有效的非竞争性 NMDA 受体拮抗剂 (可透过血脑屏障)，其 K_i 值为 6.0 μM。Orphenadrine hydrochloride 能缓解因肌肉拉伤、扭伤或其他损伤引起的僵硬、疼痛和不适，也用于缓解帕金森病引起的颤抖。Orphenadrine hydrochloride 具有较好的神经保护作用，可用于神经退行性疾病的研究。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：iGluR

In Vitro: Orphenadrine hydrochloride (12 µM; 24.5 h) shows neuroprotective effects on 3-NPA-induced neurotoxicity cerebellar granule cells.

In Vivo: Orphenadrine hydrochloride (10, 20, 30 mg/kg; i.p.; once aday for 3 days) reduces 3-NPA-induced mortality in a dose-dependent manner.
Orphenadrine hydrochloride (30 mg/kg; i.p.; once aday for 3 days) shows activity to against 3-NPA-induced neuronal damage in vivo.

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