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- 2025年12月05日
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- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
245747-71-1
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥983.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥395.0 |
| 规格： | 5 mg | 产品价格： | ￥1073.0 |
| 规格： | 10 mg | 产品价格： | ￥1838.0 |
| 规格： | 25 mg | 产品价格： | ￥3113.0 |
| 规格： | 50 mg | 产品价格： | ￥4438.0 |
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NFAT Transcription Factor Regulator-1
CAS No. : 245747-71-1
MCE 国际站：NFAT Transcription Factor Regulator-1
产品活性：NFAT Transcription Factor Regulator-1 是 IL-2 合成 的抑制剂，IC50 值为182 nM。
作用靶点：Interleukin Related
In Vitro: NFAT Transcription Factor Regulator-1 (compound example 19) inhibits IL-2 synthesis with an IC50 of 182 nM. NFAT Transcription Factor Regulator-1 inhibits human and rat PBMC proliferation with IC50s of 82 and 146 nM, respectively. NFAT Transcription Factor Regulator-1 is able to inhibit IL-4 and IL-5 production in human T-cell lines with similar potency to its effects on IL-2 release.
In Vivo: NFAT Transcription Factor Regulator-1 is found to have an inhibitory potency approximately 10-fold better than that of cyclosporine. Comparable inhibitory effects on T-cell IL-2 production are obtained with NFAT Transcription Factor Regulator-1 and cyclosporine at doses of 3.0 and 30 mg/kg, po, respectively. The efficacies achieved in monkeys in vivo for blocking T-cell cytokine production suggest that NFAT Transcription Factor Regulator-1 has potential similar to that of cyclosporine for use in transplantation.
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文献和实验Assays for Transcription Factor Activity
Most transcription activator proteins have three important features that can be probed at the molecular level: They bind to specific sequences near promoters, they can be interconverted between active and inactive forms by covalent or noncovalent
Assaying Transcription Factor Stability
Similar to the activities of transcription factors (TFs) in other eukaryotes, activities of many plant TFs are determined via regulated proteolysis by the ubiquitin/26S proteasome system. Thus, to fully understand the function of a TF
Transcription Factor Sequestration by Polyglutamine Proteins
In polyglutamine diseases including Huntington’s disease, the causative gene products containing expanded polyglutamine form nuclear aggregates in neurons. Recent studies have identified several transcriptional factors, which interact
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