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- MedChemExpress(MCE)
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- HY-109044
- 2025年07月08日
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- 详细信息
- 技术资料
- 保存条件：
4°C, protect from light
- 英文名：
WBI-1001; Benvitimod; GSK2894512
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
79338-84-4
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥990.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥409.0 |
| 规格： | 5 mg | 产品价格： | ￥900.0 |
| 规格： | 10 mg | 产品价格： | ￥1370.0 |
| 规格： | 50 mg | 产品价格： | ￥4180.0 |
| 规格： | 100 mg | 产品价格： | ￥6840.0 |
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Tapinarof
CAS No. : 79338-84-4
MCE 国际站：Tapinarof
产品活性：Tapinarof (WBI-1001) 是一种天然的芳烃受体 (AhR) 激动剂，EC50 为 13 nM。Tapinarof 可消除小鼠皮肤炎症。
作用靶点：Aryl Hydrocarbon Receptor
In Vitro: Tapinarof activates the AhR pathway through direct binding. Tapinarof dose-dependently induces nuclear translocation of AhR in immortalized keratinocytes (HaCaT) (EC50=0.16 nM).
In Vivo: Tapinarof acts through AhR to reduce inflammation in IMQ-treated mice. AhR-sufficient mice on a C57Bl/6 background exhibit a reduced clinical score after treatment with Tapinarof or 6-formylindolo(3,2-b)carbazole (FICZ). In contrast, AhR KO mice do not respond to the anti-inflammatory effects of Tapinarof. FICZ is used as a comparator in these studies and yields similar results, with dramatically reduced inflammatory responses in wild-type, but not AhR KO mice.
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