Timegadine

价格询价

品牌MedChemExpress(MCE)
产地美国
货号HY-100125
更新日期2025年06月30日

MedChemExpress LLC

品牌商

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Timegadine

CAS No. : 71079-19-1

MCE 国际站：Timegadine

产品活性：Timegadine 是一种新的抗炎药，被发现是一种有效的竞争性前列腺素合成酶抑制剂，同时也能抑制环加氧酶和脂氧合酶。

研究领域：Immunology/Inflammation

作用靶点：COX

In Vitro: Timegadine, a new antiinflammatory agent, is found to be a potent, competitive inhibitor of of COX and lipo-oxygenase, with IC₅₀s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM for lipo-oxygenase both in the cytosol fraction of horse platelet homogenates, and in washed rabbit platelets.

In Vivo: Timegadine, a new antiinflammatory agent, is found to be a potent, competitive inhibitor of prostaglandin synthetase which also inhibits cyclo-oxygenase (COX) and lipoxygenase. Daily oral doses of 10 to 30 mg/kg of Timegadine significantly inhibit both the primary and secondary lesions of adjuvant arthritis when the treatment is initiated on the day of the disease induction and continues for 28 days. Timegadine is able specifically to prevent the development of the swelling of the non-injected paw until 28 days after the adjuvant injection when administered for 5 days prior to and 5 days after the induction of the disease, in analogy with the effect of cyclophosphamide.