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- MedChemExpress(MCE)
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- 2025年12月05日
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- 文献和实验
- 技术资料
- 保存条件：
4°C, stored under nitrogen
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
821794-92-7
- 规格：
1 mg/2 mg/5 mg/10 mg/25 mg
| 规格： | 1 mg | 产品价格： | ￥679.0 |
|---|---|---|---|
| 规格： | 2 mg | 产品价格： | ￥960.0 |
| 规格： | 5 mg | 产品价格： | ￥1850.0 |
| 规格： | 10 mg | 产品价格： | ￥2800.0 |
| 规格： | 25 mg | 产品价格： | ￥4700.0 |
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FMK
CAS No. : 821794-92-7
MCE 国际站：FMK
产品活性：FMK 是一种不可逆的 RSK2 抑制剂，能够共价修饰 RSK 的 C 末端区域。
研究领域：MAPK/ERK Pathway
作用靶点：Ribosomal S6 Kinase (RSK)
In Vitro: Pretreatment of ARVMs with 3 μM fmk attenuates the increase in Ser386 phosphorylation, but it has no inhibitory effect on the increase in Thr577 phosphorylation. FMK inhibits relatively few protein kinases in the panel, although it does inhibit protein tyrosine kinases, such as Src, Lck, Yes and Eph-A2, as well as S6K1. FMK will not inhibit RSK if the N-terminal kinase domain are activated by a mechanism that is independent of the C-terminal domain. Fmk potently inactivates the CTD auto-kinase activity of RSK1 and RSK2 with high specificity in mammalian cells. Targeting RSK2 by a specific small molecule RSK inhibitor fmk attenuates FGFR3-induced cytokine-independent growth in Ba/F3 cells. FMK inhibits cytokine-independent proliferation of Ba/F3 cells conferred by FGFR3.
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文献和实验活细胞内总的Caspase 的活性。 2、Caspase Activity Detection Kit (Red-VAD-FMK) 目录号：QIA92 包装：100T/Kit 本试剂盒为您提供了一种快速而灵敏的活细胞内的Caspase 活性的荧光检测方法，所有操作可以在1.5 小时内完成；可以用荧光显微镜、荧光读板仪或流式细胞仪对实验结果进行定量分析；其荧光为红色荧光，最大激发波长约为540nm，最大发射波长约为570nm。本试剂盒可用于多种种属来源的Caspase 的活性检测，其特别
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