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- 保存条件：
Powder: -20°C, 3 years.In solvent: -80°C, 6 months; -20°C, 1 month.
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货期：1-2天
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MedChemExpress LLC
- CAS号：
2314467-59-7
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10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1184.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥734.0 |
| 规格： | 5 mg | 产品价格： | ￥1200.0 |
| 规格： | 10 mg | 产品价格： | ￥1900.0 |
| 规格： | 25 mg | 产品价格： | ￥3800.0 |
| 规格： | 50 mg | 产品价格： | ￥6000.0 |
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TRPV4 agonist-1 free base
CAS No. : 2314467-59-7
MCE 国际站：TRPV4 agonist-1 free base
产品活性：TRPV4 agonist-1 free base 是一种瞬时受体电位香草酸亚型 4 (TRPV4) 激动剂，在 hTRPV4 Ca2+ 实验中 EC50 为 60 nM。
研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling
作用靶点：TRP Channel
In Vitro: TRPV4 agonist-1 (Compound 36) exhibits significantly increased potency (ECmax: 20 nM in the SOX9 reporter assay). TRPV4 agonist-1 is inactive against TRPV1 channels.
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文献和实验Transient receptor potential vanilloid 4 (TRPV4) was first identified in 2000 as an osmolarity sensor. Further investigations rapidly revealed this ion channel to be a polymodal receptor with additional activating or modulating stimuli
Ca2+ Imaging as a Tool to Assess TRP Channel Function in Murine Distal Nephrons
, namely, in the freshly isolated distal nephrons, with a special emphasis on the mechanosensitive TRPV4 channel and its role in tubular flow sensing.
Transient Receptor Potential Channels and Pruritus
of the skin surface temperature which has a major impact on the epidermal permeability barrier. TRPV1 has an important role in the induction of histamine-mediated pruritus in sensory neurons while TRPV4 has a role to play in histamine-independent itch
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