HSK0935,1638851-44-1

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HSK0935

CAS No. : 1638851-44-1

MCE 国际站：HSK0935

产品活性：HSK0935是高效，高选择性，口服可用的 SGLT2 抑制剂。IC₅₀为1.3 nM。具有抗高血糖功效。

研究领域：Membrane Transporter/Ion Channel

作用靶点：SGLT

In Vitro: HSK0935 (Compound 31) demonstrates excellent hSGLT2 inhibition of 1.3 nM and a high hSGLT1/hSGLT2 selectivity of 843-fold.

In Vivo: HSK0935 treatment (1, 3, and 10 mg/kg) shows robust urinary glucose excretion in Sprague−Dawley (SD) rats and affects more urinary glucose excretion in Rhesus monkeys.

HSK0935 is well tolerated up to 300 mg/kg without any mortality or severe untoward effects in a 28-day repeat-dose toxicology study in beagle dogs.

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