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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
HOE-642 Free Base
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
159138-80-4
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥605.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥250.0 |
| 规格： | 5 mg | 产品价格： | ￥550.0 |
| 规格： | 10 mg | 产品价格： | ￥770.0 |
| 规格： | 50 mg | 产品价格： | ￥3300.0 |
| 规格： | 100 mg | 产品价格： | ￥5900.0 |
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Cariporide
CAS No. : 159138-80-4
MCE 国际站：Cariporide
产品活性：Cariporide (HOE-642) 是选择性的 Na+/H+ 交换抑制剂。
研究领域：Membrane Transporter/Ion Channel
In Vitro: Cariporide significantly suppresses markers of cell death, such as TUNEL positivity and caspase-3 cleavage, at 8 or 16 hours. Cariporide remarkably suppresses cytosolic Na+ and Ca2+ accumulation. Cariporide prevents mitochondrial membrane potential loss induced by H2+O2+. Cariporide (HOE-642) ameliorates myocardial ischemia/reperfusion injury, by the well-established reduction of cytosolic Ca2+ in cardiac myocytes through inhibition of Na+/H+ exchange. Cariporide (HOE-642), has inhibitory effects on the degranulation of human platelets, the formation of platelet–leukocyte-aggregates, and the activation of the GPIIb/IIIa receptor (PAC-1).
In Vivo: Intravenous administration of cariporide significantly decreases brain Na+ uptake and reduces cerebral edema, brain swelling, and infarct volume.
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