RWJ-51204,205701-85-5

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

RWJ-51204

CAS No. : 205701-85-5

MCE 国际站：RWJ-51204

产品活性：RWJ-51204 是 GABA(A) receptor 的部分激动剂，K_i 值为 0.2-2 nM。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：GABA Receptor

In Vitro: RWJ-51204 binds to receptors in the cerebral cortex, cerebellum, or medulla-spinal cord with K_i ranging from 0.2 to 0.6 nM.

In Vivo: RWJ-51204 is orally active in anxiolytic efficacy tests. WJ 51204 dose-relatedly antagonizes PTZ-induced clonic convulsions when administered orally (ED₅₀ = 0.04 mg/kg). RWJ-51204 is effective in the conflict test in monkeys (ED₅₀ of approximately 0.5 mg/kg p.o.). RWJ-51204 potently impairs rotarod performance in rats (ED₅₀ = 0.12 mg/kg), and all rats given RWJ-51204 orally at 30 mg/kg exhibit sedation, reduced skeletal muscle tone, and impairment of rotarod performance.

相关产品：Bicuculline  |  γ-Aminobutyric acid  |  Picrotoxin  |  Aminooxyacetic acid hemihydrochloride  |  Propofol  |  Gabazine  |  Riluzole  |  Furosemide  |  Baclofen  |  Amentoflavone  |  Zuranolone  |  CGP52432  |  Vigabatrin  |  Flumazenil  |  Dihydroergotoxine mesylate  |  Methionine  |  Tiagabine hydrochloride  |  Etiocholanolone  |  L-Cycloserine  |  Topiramate  |  Jujuboside A  |  THIP  |  SKF89976A hydrochloride  |  Ginsenoside Rc  |  Basmisanil  |  Clomethiazole  |  Broflanilide  |  Isoguvacine hydrochloride

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds