VU 0240551,893990-34-6

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VU 0240551

CAS No. : 893990-34-6

MCE 国际站：VU 0240551

产品活性：VU 0240551 是一种有效的神经元 K-Cl 协同转运蛋白 KCC2 抑制剂 (IC₅₀=560 nM)，与 NKCC1 相比具有选择性。VU 0240551 也抑制 hERG 和 L 型 Ca²⁺ 通道。VU 0240551 减弱 GABA 诱导的 P 细胞超极化，使 P 细胞 GABA 逆转电位发生正移，增强 P 细胞突触传递。

研究领域：Membrane Transporter/Ion Channel

作用靶点：Potassium Channel

In Vitro: VU 0240551 reduces the P cell response to GABA in a concentration-dependent manner with 75 and 100 μM treatments causing a significant reduction in GABA-elicited hyperpolarization while 25 μM had no significant effect.

In Vivo: VU 0240551 (10 μM) significantly blocks the chloride influx in cells from Eu rats but did not affect cells from SL rats.

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