- ￥800 - 3900
- MedChemExpress(MCE)
- 美国
- HY-100668
- 2026年05月21日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
相关阅读
源叶生物 十万种现货试剂速发，品质稳、品类全，实验不再等！Takara 秋促来袭，提取+反转录+定量套装仅 1200 元abinScience 体内级抗体 全年锁价 低至 ￥1200阿拉丁 22万+ 科研级产品现货速发，品质严控、科研无忧- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
SC 0030
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
401907-26-4
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥2236.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥800.0 |
| 规格： | 5 mg | 产品价格： | ￥2400.0 |
| 规格： | 10 mg | 产品价格： | ￥3900.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
JYL 1421
CAS No. : 401907-26-4
MCE 国际站：JYL 1421
产品活性：JYL 1421 是 TRPV1 受体的一个拮抗剂，其 IC50 值为 8 nM。
研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling
作用靶点：TRP Channel
In Vitro: Incubation with JYL 1421 for 5 min concentration-dependently inhibits the capsaicin (330 nM)-evoked Ca2+ accumulation. The inhibitory effect of the lowest concentration (5 nM) of JYL 1421 reaches the level of significance and 1 μM almost abolishes the response, only 3.1±0.65% of the first capsaicin-induced Ca2+ influx could be observed. The IC50 value is 8 nM for JYL 1421. Meanwhile, the effect of capsazepine is markedly smaller, it induces 41.7% inhibition in 1 μM concentration, but this inhibitory effect does not increase further in 10 μM and does not reach 50%.
In Vivo: Instillation of 50 μL capsaicin solution (10 μg/mL) into the left eye of the rat evokes 12.9±1.3 wiping movements within 3 min. Pretreating the rats with 0.4 or 1 mg/kg i.p. JYL 1421 does not influence significantly the wiping behavior, but 2-5 mg/kg dose-dependently reduces the number of wiping movements. The ID50 value is 4.6 mg/kg. The mean arterial pressure of untreated rats is 109.9±4.2 Hgmm (n=6). One and 2 μg/kg capsaicin i.v. injection evokes a transient drop of blood pressure by 47.4±4.7 and 59.6±4.2 Hgmm (n=6), respectively. Both applied doses of JYL 1421 (0.4 and 1.6 mg/kg) fail to evoke hypotension. JYL 1421 dose-dependently inhibits the capsaicin-induced fall in blood pressure as shown by the need for higher capsaicin doses to elicit the reflex hypotension after JYL 1421 administration than before treatment. Capsazepine fails to induce a significant inhibition of the capsaicin-evoked hypotension up to a dose of 2 mg/kg.
相关产品：Bioactive Compound Library Plus | Membrane Transporter/Ion Channel Compound Library | Neuronal Signaling Compound Library | Mechanoreceptors Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Ion Channel Compound Library | Rosiglitazone | Capsaicin | GsMTx4 | EIPA | Probenecid | Diphenyleneiodonium chloride | 2-Aminoethyl diphenylborinate | Amiloride hydrochloride | GSK1016790A | Capsazepine | HC-067047 | HC-030031 | ML-SA1 | GSK2193874 | Adenosine 5′-diphosphoribose sodium | AMG9810 | GSK205 | SKF-96365 hydrochloride | (-)-Menthol | Caffeic acid | ML-SI1 | BI-749327 | GSK2798745 | Pregnenolone | ML-SA5 | N-(p-amylcinnamoyl) Anthranilic Acid | A-967079 | MK6-83 | Pico145
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验时间不宜超过 2min。 25、将细胞悬液转移至 15ml 离心管中，加入 10ml 预冷的 DMEM/F12 培养基（含 10% FBS）。4℃ 条件下 220g 离心 5min，取细胞沉淀。 26、将所得细胞重复 8-12 步骤，完成 OC 类器官复苏。 图 2. OC 类器官的不同形态表型。即致密（左），囊性（中）和低内聚（右）型 OC 类器官。比例尺 200 μm【4】。 卵巢癌类器官样本来源不局限于活检样本或手术样本，腹水和胸腔积液中的癌细胞也同样可以用于构建 OC 类器官。培养
field-flow fractionation with chemiluminescence detection for flow-assisted, multianalyte assays in heterogeneous phase. Reschiglian, P. et al. (2003) J. Sep. Science 26, 1417–1421
1421-1432. 15. Alban, A., David, S. 0 ., Bjorkesten, L., et al. (2003) A novel experimental designfor comparative two-dimensional gel analysis: two- dimensional difference gel electrophoresis incorporating a pooled internal standard. P r o te o
技术资料暂无技术资料 索取技术资料
