- ￥2660 - 8600
- MedChemExpress(MCE)
- 美国
- HY-100298
- 2025年07月11日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 保存条件：
4°C, protect from light
- 英文名：
MCC-135
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
133804-44-1
- 规格：
1 mg/5 mg/10 mg
| 规格： | 1 mg | 产品价格： | ￥2660.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥6140.0 |
| 规格： | 10 mg | 产品价格： | ￥8600.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Caldaret
CAS No. : 133804-44-1
MCE 国际站：Caldaret
产品活性：Caldaret 是一种细胞内 Ca2+ 调节剂，通过反向模式抑制 Na+/Ca2+ 交换作用。
研究领域：Membrane Transporter/Ion Channel
作用靶点：Na+/Ca2+ Exchanger
In Vitro: Caldaret (MCC-135) is demonstrated to restore Ca2+-ATPase activity of the sarcoplasmic reticulum (SR) isolated from the myocardium acutely exposed to ischemia and reperfusion in vitro.
In Vivo: Caldaret, an intracellular Ca2+ handling modulator, limits infarct size of reperfused canine heart. The cardioprotective effect of Caldaret, a novel intracellular Ca2+ handling modulator that acts through reverse-mode Na+/Ca2+ exchanger inhibition and potential sarcoplasmic reticulum (SR) Ca2+ uptake enhancement, against reperfusion injury is investigated. Intravenously infused Caldaret (3 or 30 microg/kg per hour) for 30 min at left circumflex (LCX)-reperfusion markedly reduces infarct size (by 51.3% or 71.9%, respectively). The amelioration of intracellular Ca2+ handling dysfunction achieved by Caldaret leads to cardioprotective effects against reperfusion injury following prolonged ischemia. Caldaret (MCC-135) is a new potent compound with beneficial effects in heart failure. In diabetic rats, Caldaret decreases TR80 significantly without significant effect on developed tension (DT). Caldaret has minimal effects on SR Ca2+ uptake in normal rats, that is observed as increased SR Ca2+ uptake at uptake time of 20 and 30 s at the highest concentration of 10 μM. In diabetic rats, Caldaret increases SR Ca2+ uptake all over the range of uptake time. Both initial rate of SR Ca2+ uptake and the amount of Ca2+ accumulated in the SR with longer uptake time are increased by Caldaret.
相关产品：CGP37157 | Terfenadine | KB-R7943 mesylate | SEA0400 | Benzamil hydrochloride | PPADS tetrasodium | ORM-10962 | SN 6 | ORM-10103 | YM-244769 | SM-6586
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
