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Thrombin inhibitor 1
CAS No. : 855998-46-8
MCE 国际站：Thrombin inhibitor 1
产品活性：Thrombin inhibitor 1 是一种有效的凝血酶抑制剂 (Ki=0.66 nM，2xaPTT=0.43 μM)。
研究领域：Metabolic Enzyme/Protease
作用靶点：Thrombin
In Vitro: Thrombin inhibitor 1 (Compound 4) is binds in the active site of thrombin with Ki of 0.66 nM, 2xaPTT=0.43 uM). Thrombin inhibitor 1 (Compound 4) is evaluated for its thrombin inhibitory potency and its functional ability to double the activated partial thromboplastin time (2xaPTT) in human plasma with a 2xaPTT of 0.43 μM.
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文献和实验Oral Thrombin Inhibitor Ximelagatran
Preclinical and initial clinical experiences with the direct oral thrombin inhibitor ximelagatran demonstrated both a short and long-term potential utility for this agent in the prevention and treatment of various thromboembolic disorders
at the meeting of the International Society in Thrombosis and Haemostasis in 1993. AT is an important protease inhibitor of thrombin and factor Xa. However, AT is also able to inhibit factors IXa, XIa, XIIab, kallikrein, and plasmin. Given
Antiplatelet, Anticoagulant, and Thrombolytic Drug Interactions
, but heparin anticoagulation is unpredictable because it is an indirect thrombin inhibitor, which requires heparin cofactor II-antithrombin for its actions. Antithrombin levels vary widely in patients. In addition, the heparin-antithrombin complex is too large
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