Ecopladib,381683-92-7

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Ecopladib

CAS No. : 381683-92-7

MCE 国际站：Ecopladib

产品活性：Ecopladib 是一种胞浆磷脂酶 A2α (phospholipase A2α) 抑制剂，在 GLU micelle 和大鼠全血细胞中，IC₅₀ 值分别为 0.15 μM 和 0.11 μM。

研究领域：Metabolic Enzyme/Protease

作用靶点：Phospholipase

In Vitro: Ecopladib inhibits cPLA2α in the PAPE liposome assay at 73% at a concentration of 37 nM, while it inhibits sPLA2 at 16% at 1 μM. Ecopladib inhibits the production of prostaglandins (PGF2α) and leukotrienes (LTB4 and LTC4/D4/E4) with comparable IC₅₀s of 20−30 nM. Ecopladib is inactive against COX-1 and COX-2 at 20 μM, which is nearly 100 times the IC₅₀ in the MC-9 cells. Ecopladib inhibit 12- and 15-HETE, which are derived from arachidonic acid via the 12- and 15-lipoxygenase pathways and the IC₅₀s are ∼0.3 μM.

In Vivo: Ecopladib is orally efficacious in this model and displays an ED₅₀ of 8 mg/kg, demonstrating that it can inhibit COX-2 derived PGE2 formation in vivo. Ecopladib is orally efficacious at reducing carrageenan-induced paw swelling: from dose−response studies, it is determined that the ED₅₀ is 40 mg/kg.

相关产品：GW4869  |  Neomycin sulfate  |  U-73122  |  BAPTA  |  Compound 48/80 trihydrochloride  |  Omeprazole  |  D609  |  Darapladib  |  ML348  |  m-3M3FBS  |  ML349  |  Varespladib  |  N-(p-amylcinnamoyl) Anthranilic Acid  |  Tris(2,4-di-tert-butylphenyl)phosphate  |  MAFP  |  Tanshinone I  |  Lansoprazole  |  FIPI  |  CAY10650  |  U-73343  |  DPTIP  |  3-Nitrocoumarin  |  AACOCF3  |  LEI-401  |  Bromoenol lactone  |  Cambinol  |  Melittin TFA  |  AA26-9  |  Manumycin A

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds