Tebuconazole戊唑醇,107534-96-3

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Tebuconazole

CAS No. : 107534-96-3

MCE 国际站：Tebuconazole

产品活性：Tebuconazole 是一种农用唑类杀菌剂也能抑制 CYP51 ，对于白色念珠菌 CYP51 (CaCYP51) 和人 CYP51 截短体 (Δ60HsCYP51) 的 IC₅₀ 值分别为 0.9 和 1.3 μM。Tebuconazole 诱导 HepG2 细胞中的脂质积累和氧化应激。Tebuconazole 可降低 MAC-T 细胞活力和增殖，诱导内质网应激介导的细胞凋亡，并增加 MAC-T 细胞的氧化应激水平。

研究领域：Metabolic Enzyme/Protease  |  Anti-infection

作用靶点：Cytochrome P450  |  Fungal

In Vitro: Tebuconazole (TEB) (20–80 μM, 24 h) shows lipid accumulation in HepG2 cells.
Tebuconazole (20–80 μM, 12 h) increases the nuclear translocation of peroxisome proliferator-activated receptors and the expression of lipid uptake and oxidation-related markers in HepG2 cells.
Tebuconazole (20–80 μM, 24 h) increases oxidative stress levels, induces the loss of mitochondrial membrane potential and lower levels of microsomal triglyceride transfer protein in the HepG2 cells.
Tebuconazole (0-750 μM, 24 hours) decreases MAC-T cells viability and proliferation and induced mitochondria-mediated apoptotic MAC-T cell death by activating ER stress.
Tebuconazole (0-100 μM, 24 hours) induces dose-dependent cell death in H9c2 cardiomyoblasts and in adult rat ventricular myocytes (ARVM).
Tebuconazole (30-60 μM, 24 hours) induces DNA damage and ROS generation and lipid peroxidation in H9c2 cells.

In Vivo: Tebuconazole (TEB) (10-50 mg/kg, p.o., once daily for 28 days) induces a multiplicity of CYPs and oxidative stress in liver; inhibits testicular P450 and glutathione S-transferase activities; and produces anti-androgenic effects in male rats.
Tebuconazole (25-100 mg/kg, p.o., daily for 10 days) causes the proliferation of fetal Leydig cells and increases fetal serum testosterone and progesterone levels in gestational rat.

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