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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
Tetrahydrolipstatin; Ro-18-0647
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/100 mg/200 mg/500 mg/1 g
| 规格： | 10 mM * 1 mL | 产品价格： | ￥992.0 |
|---|---|---|---|
| 规格： | 100 mg | 产品价格： | ￥902.0 |
| 规格： | 200 mg | 产品价格： | ￥1262.0 |
| 规格： | 500 mg | 产品价格： | ￥2020.0 |
| 规格： | 1 g | 产品价格： | ￥2626.0 |
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Orlistat
CAS No. : 96829-58-2
MCE 国际站：Orlistat
产品活性：Orlistat (Tetrahydrolipstatin) 是一种不可逆的胰腺和胃脂肪酶 (lipases) 抑制剂。 Orlistat也是一种脂肪酸合成酶 (FASN) 抑制剂，口服用于肥胖症的长期研究。具有抗动脉粥样硬化作用。
研究领域：Metabolic Enzyme/Protease | Apoptosis
作用靶点：Fatty Acid Synthase (FASN) | Apoptosis
In Vitro: Orlistat (40 μM; 2 days) does not affect MGMT levels in a human melanoma cell line, but downregulates the repair protein by 30-70% in human peripheral blood mononuclear cells, in two leukemia and two colon cancer cell lines. Orlistat does not alter noticeably MGMT mRNA expression.
In Vivo: Orlistat (10 mg/kg/day) significantly improves lipid profile, increases antioxidant enzymes and expression of anti-inflammatory markers, and decreases the expression of the pro-inflammatory marker compared to the obese (OB) group.
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