Mardepodect,2070014-78-5

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Mardepodect hydrochloride

CAS No. : 2070014-78-5

MCE 国际站：Mardepodect hydrochloride

产品活性：Mardepodect hydrochloride (PF-2545920 hydrochloride) 是一种有效的，口服活性的，选择性的 PDE10A 抑制剂，IC₅₀ 为 0.37 nM，比作用于其他 PDE 选择性高 1000 多倍。Mardepodect hydrochloride 可穿过血脑屏障。

研究领域：Metabolic Enzyme/Protease

作用靶点：Phosphodiesterase (PDE)

In Vivo: In the conditioned avoidance response assay (CAR), Mardepodect (PF-2545920) is active with an ED₅₀ of 1 mg/kg. Administration of Mardepodect (PF-2545920) to mice causes a dose dependent increase in striatal cGMP.

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