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4°C, sealed storage, away from moisture and light
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货期：1-2天
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10 mM * 1 mL///1 mg
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JTT 551
CAS No. : 776309-04-7
MCE 国际站：JTT 551
产品活性：JTT 551 是一种选择性的蛋白酪氨酸磷酸酶 1B (PTP1B) 抑制剂，Ki 值为 0.22 μM，同时对 T 细胞蛋白酪氨酸磷酸酶 (TCPTP）也有作用，Ki 值为 9.3 μM，可用于二型糖尿病的研究。
研究领域：Metabolic Enzyme/Protease
作用靶点：Phosphatase
In Vitro: JTT 551 is selective a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with Kis of 0.22 μM and 9.3 μM for PTP1B and TCPTP (T-cell protein tyrosine phosphatase), respectively. JTT 551 shows low affinity at CD45 PTP (CD45) and leucocyte common antigen-related (LAR) PTP with Kis of both >30 μM. Furthermore, JTT-551 (10 and 30 μM) enhances the insulin-induced deoxyglucose uptake in a dosedependent manner.
In Vivo: JTT 551 (3 mg/kg, 30 mg/kg, p.o.) dose-dependently decreases blood glucose level on Days 7, 14 and 28 in db/db Mice. JTT 551 also significantly reduces triglyceride (TG) level at 30 mg/kg on Day 7 but does not alter insulin and total cholesterol (TC) levels.
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文献和实验：1. 在默认参数下，FastTree 比 PhyML 更准确，比 PhyML 快 100～1000 倍；2. FastTree 使用模型为：核酸进化模型：Jukes-Cantor 或者 GTR（generalized time-reversible）；蛋白进化模型：JTT (Jones-Taylor-Thornton 1992)， WAG (Whelan & Goldman 2001) 或者 LG (Le and Gascuel 2008)下载，安装 FastTreeFastTree 提供以下几个版本
2.750 3.646 11 2.201 3.106 4.437 40 2.021 2.704 3.551 12 2.179 3.055 4.318 50 2.008 2.678 3.496 13 2.160 3.012 4.221 60 2.000 2.660 3.460 14 2.145 2.977 4.140 70 1.994 2.648 3.435 15 2.131 2.947 4.073 80 1.989 2.638 3.416 16 2.120 2.921 4.015 90
Proteasome Preparation from Human Brain
with water. Make up the Homogenising Buffer (3ml/g tissue) in the following way:- Tris 500mM = 30.3g/500ml. Adjust to pH7.5 with HCl. ATP 100mM = 0.551g/10ml. Adjust to pH7.5 with NaOH (can be stored at -20°C). MgCl2 50mM = 1.02g/100ml. DTT
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