JTT 551,776309-04-7

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JTT 551

CAS No. : 776309-04-7

MCE 国际站：JTT 551

产品活性：JTT 551 是一种选择性的蛋白酪氨酸磷酸酶 1B (PTP1B) 抑制剂，K_i 值为 0.22 μM，同时对 T 细胞蛋白酪氨酸磷酸酶 (TCPTP）也有作用，K_i 值为 9.3 μM，可用于二型糖尿病的研究。

研究领域：Metabolic Enzyme/Protease

作用靶点：Phosphatase

In Vitro: JTT 551 is selective a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with K_is of 0.22 μM and 9.3 μM for PTP1B and TCPTP (T-cell protein tyrosine phosphatase), respectively. JTT 551 shows low affinity at CD45 PTP (CD45) and leucocyte common antigen-related (LAR) PTP with K_is of both >30 μM. Furthermore, JTT-551 (10 and 30 μM) enhances the insulin-induced deoxyglucose uptake in a dosedependent manner.

In Vivo: JTT 551 (3 mg/kg, 30 mg/kg, p.o.) dose-dependently decreases blood glucose level on Days 7, 14 and 28 in db/db Mice. JTT 551 also significantly reduces triglyceride (TG) level at 30 mg/kg on Day 7 but does not alter insulin and total cholesterol (TC) levels.

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