- ￥1590 - 5500
- MedChemExpress(MCE)
- 美国
- HY-19485
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥4240.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1590.0 |
| 规格： | 5 mg | 产品价格： | ￥3500.0 |
| 规格： | 10 mg | 产品价格： | ￥5500.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
XL-784
CAS No. : 1224964-36-6
MCE 国际站：XL-784
产品活性：XL-784 是 MMP 的一个选择性抑制剂，其对 MMP-1，MMP-2，MMP-3，MMP-8，MMP-9，MMP-13 的 IC50 值分别约为 1900，0.81，120，10.8，18，0.56 nM。
研究领域：Metabolic Enzyme/Protease
作用靶点：MMP
In Vitro: XL-784 is a highly potent, low-molecular-weight (1,122 g/mol) inhibitor of MMPs that has very limited aqueous solubility (20 μg/mL). XL-784 potently inhibits MMP-2, MMP-13, andADAM10 [TNF-α-converting enzyme (TACE)] activity in vitro, with IC50 values in the range of 1-2 nM. XL-784 also inhibits MMP-9 (IC50 ~20 nM) activity and ADAM17 (IC50 ~70 nM) also known as TACE. However, it exhibits low potency for inhibition of MMP-1 (IC50 ~2,000 nM).
In Vivo: All mice tolerate the treatments similarly. Control mice all developed aneurysms with a mean %△AD of 158.5%±4.3%. Treatment with all doses of XL-784 and doxycycline are effective in inhibiting aortic dilatation. There is a clear dose-response relationship between XL-784 and reductions in aortic dilatation at harvest (50 mg/kg 140.4% ±3.2%; 125 mg/kg 129.3% ±5.1%; 250 mg/kg 119.2%±3.5%; all Ps<0.01 compared to control). This continues with the higher doses (375 mg/kg 88.6%±4.4%; 500 mg/kg 76.0%±3.5%). The highest 2 doses of XL-784 tested are more effective than doxycycline (112.2%±2.0%, P<0.05) in inhibiting maximal dilatation of the aorta after elastase perfusion.
相关产品：Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Metabolism/Protease Compound Library | Clinical Compound Library | Drug Repurposing Compound Library | Differentiation Inducing Compound Library | Anti-Cardiovascular Disease Compound Library | Anti-Pancreatic Cancer Compound Library | Angiogenesis-Related Compound Library | Targeted Diversity Library | Anti-Pulmonary Fibrosis Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Highly Selective Inhibitors Library | Doxycycline hyclate | T-5224 | Ilomastat | Chloramphenicol | Astragaloside IV | Edaravone | Isoginkgetin | Cordycepin | Marimastat | GI254023X | Stigmasterol | Salvianolic acid A | o-Phenanthroline | Arctigenin | Actinonin | SB-3CT | Meloxicam | Batimastat | MMP-9-IN-1 | Chondroitin sulfate | GW280264X | TAPI-1 | Aderbasib | Tranexamic acid | (-)-Epigallocatechin | Incyclinide | TAPI-2 | Indinavir sulfate | ARP-100
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验for 30-60 minutes. 3. Heat the reaction at 65degC for 10 minutes to inactivate the kinase. G. Bacterial cell maintenance Four strains of E. coli are used in these studies: JM101 for M13 infection and isolation (4), XL1BMRF
Bax- Bcl-XL二聚体中的Bax单位，进而促进细胞死亡。在体外，发现Bcl-2家族可能还对离子通道有影响。 Annexin V检测凋亡细胞的质膜变化 细胞发生凋亡时会有一系列的形态学特征性改变，其中，质膜的改变是早期凋亡的特征之一。细胞发生凋亡时，胞膜磷脂酰丝氨酸（PS）从胞膜内侧翻转到外侧，暴露于细胞外表面。Annexin V是一个35-36kD的Ca2+依赖性的磷脂结合蛋白，它与磷脂酰丝氨酸有高度亲和力，可以与细胞外暴露的磷脂酰丝氨酸结合。Annexin V标记上FITC、PE或生物
Basic procedures for bacteria culture
G. Bacterial cell maintenance Four strains of E. coli are used in these studies: JM101 for M13 infection and isolation (4), XL1BMRF' (Stratagene) for M13 or pUC-based DNA transformation (5), and ED8767 for cosmid DNA transformation
技术资料暂无技术资料 索取技术资料
