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- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
Calpain Inhibitor III
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥880.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥363.0 |
| 规格： | 5 mg | 产品价格： | ￥800.0 |
| 规格： | 10 mg | 产品价格： | ￥1200.0 |
| 规格： | 25 mg | 产品价格： | ￥2400.0 |
| 规格： | 50 mg | 产品价格： | ￥4300.0 |
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MDL-28170
CAS No. : 88191-84-8
MCE 国际站：MDL-28170
产品活性：MDL-28170 (Calpain Inhibitor III) 是一种有效的、选择性的、具有膜渗透性的半胱氨酸蛋白酶 (calpain)抑制剂，可在全身给药后迅速穿过血脑屏障。MDL-28170 还能阻断γ-secretase。
研究领域：Metabolic Enzyme/Protease
作用靶点：Proteasome
In Vitro: MDL-28170 significantly and time-dependently improves the recovery of synaptic responses in hippocampal slices following prolonged, moderate hypoxia without hypoxic depolarization.
?MDL-28170 dose-dependently inhibits brain cysteine proteinase activity (in vitro Ki= 0.01 μM).
In Vivo: Treatment with MDL-28170 (50 mg/kg, i.p.) completely prevents the striatal damage in four animals in each of the two treatment groups. The numbers of necrotic neurons are reduced by 85% and 68% in animals in which MDL-28170 injections are initiated at 0.5 and 3 h of recirculation, respectively.
?MDL-28170 (30 mg/kg, i.p.) reduces the functional and structural deterioration of corpus callosum following fluid percussion injury.
?MDL-28170 (10 mg/kg, i.p.) significantly improves nerve function parameters in diabetic rats. MDL-28170 (3 and 10 mg/kg, i.p.) improves nociceptive behavior in diabetic rats.
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文献和实验Purification and Characterization of Crustacean Calpain-like Proteinases
, and have a much greater affinity for Ca2+ than for other divalent cations (3 –6 ). Invertebrate calpain-like enzymes are strongly inhibited by cysteine proteinase inhibitors, such as E-64 and related epoxysuccinyl peptides, peptide aldehydes (e.g., MDL 28170
[3H](+)MK801 Radioligand Binding Assay at the N‐Methyl‐D‐Aspartate Receptor
., Siegel, B.W., Harrison, B.L., Gross, R.S., Hawes, C., and Towers, P. 1996. [3H]MDL 105,519, a high‐affinity radioligand for the N‐methyl‐D‐aspartate receptor‐associated glycine recognition site J. Pharmacol. Exp. Ther. 279:62‐68
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