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- 2025年07月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
AY-27773
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1320.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥545.0 |
| 规格： | 5 mg | 产品价格： | ￥1200.0 |
| 规格： | 10 mg | 产品价格： | ￥1900.0 |
| 规格： | 50 mg | 产品价格： | ￥6600.0 |
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Tolrestat
CAS No. : 82964-04-3
MCE 国际站：Tolrestat
产品活性：Tolrestat 是一种有效的，可口服的 aldose reductase 抑制剂，IC50 值为 35 nM。
研究领域：Metabolic Enzyme/Protease
作用靶点：Aldose Reductase
In Vivo: Tolrestat (1.8 mg/kg per day) causes a reversal to normal RBC sorbitol levels diabetic rats. In 21-day diabetic rats, the estimated ID in the sciatic nerve and lenses is 4.8 and about 20 for tolrestat, and 1.7 and 2.2 for (±)sorbinil,respectively. Either tolrestat or sorbinil inhibits tissue AR activity but does not significantly affect plasma lipoprotein levels, or affect the body weight of the mice or their general health. Accumulation of cholesterol-rich foam cells is significantly increased in aortic roots of tolrestat-fed mice.
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