Vildagliptin dihydrate维格列汀二水合物

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Vildagliptin dihydrate

CAS No. : 2133364-01-7

MCE 国际站：Vildagliptin dihydrate

产品活性：Vildagliptin dihydrate (LAF237 dihydrate) 是一种有效且稳定的选择性二肽基肽酶IV (DPP-IV) 抑制剂，在人 Caco-2 细胞中抑制 DPP-IV 的 IC₅₀ 为 3.5 nM。Vildagliptin dihydrate 具有出色的口服生物利用度和有效的降血糖活性。

研究领域：Metabolic Enzyme/Protease  |  Apoptosis

作用靶点：Dipeptidyl Peptidase  |  Ferroptosis  |  Apoptosis

In Vitro: Vildagliptin promotes beta cell survival by inhibiting cell apoptosis. Vildagliptin also promotes cell proliferation.

In Vivo: Vildagliptin (35 mg/kg; once daily by oral gavage) increases plasma active GLP-1 levels in islets of db/db mice.
Vildagliptin (10 µmol/kg; orally) significantly decreases glucose excursions and stimulate insulin secretion in obese male Zucker rats.

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