BMS-654457,1004551-41-0

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

BMS-654457

CAS No. : 1004551-41-0

MCE 国际站：BMS-654457

产品活性：BMS-654457是 (FXIa) 的小分子可逆抑制剂，与人和兔FXIa结合的K_i 值分别为 0.2 和 0.42 nM。

研究领域：Metabolic Enzyme/Protease

作用靶点：Factor Xa

In Vitro: BMS-654457 shows comparable in vitro potency against FXIa in humans (Ki=0.2 nM) and in rabbits (Ki =0.42 nM), and was over 500-fold selective against coagulation-related proteases (thrombin, FXa and FVIIa) in these species.

In Vivo: BMS-654457 is effective in the prevention of arterial thrombosis in rabbits with limited effects on bleeding time. BMS-654457 is a promising antithrombotic therapy with a wide therapeutic window.

相关产品：Heparin sodium salt  |  Rivaroxaban  |  Apixaban  |  Edoxaban  |  Fondaparinux sodium  |  Asundexian  |  Milvexian  |  Betrixaban  |  Gabexate mesylate  |  Enoxaparin  |  Otamixaban  |  BMS-262084  |  Garadacimab  |  Abelacimab  |  Darexaban  |  5-R-Rivaroxaban  |  BMS-962212  |  Fitusiran  |  Bismuth subgallate  |  ARC19499  |  D-Pro-Phe-Arg-Chloromethylketone  |  Dechloro Rivaroxaban  |  Edoxaban impurity 4

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds