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货期：1-2天
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- CAS号：
39122-38-8
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| 规格： | 1 mg | 产品价格： | ￥750.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥1600.0 |
| 规格： | 10 mg | 产品价格： | ￥2500.0 |
| 规格： | 25 mg | 产品价格： | ￥5000.0 |
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NSC 185058
CAS No. : 39122-38-8
MCE 国际站：NSC 185058
产品活性：NSC 185058 是一种 ATG4B 抑制剂。ATG4B 是一种主要的半胱氨酸蛋白酶 (cysteine protease)。NSC185058 抑制 ATG4B 从而显著减弱自噬 (autophagic) 活性。
研究领域：Autophagy
In Vivo: NSC185058 is an ATG4B antagonist. ATG4B stimulates autophagy by promoting autophagosome formation through reversible modification of ATG8. Inclusion of the ATG4B inhibitor NSC185058 enhances the anti-tumor activity of radiation therapy (RT). NSC185058 decreases glioblastoma (GBM) cell tumorigenicity, and enhances the anti-tumor activity of RT when applied to orthotopic GBM xenograft models.
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文献和实验Neurosphere and Neural Colony-Forming Cell Assays
), neural stem cells (NSC) are often isolated and studied using a culture system referred to as the neurosphere assay. Since its introduction in 1992, the neurosphere system has been used to isolate, expand, and identify the presence of an NSC population
Methods for Analysis of Brain Tumor Stem Cell and Neural Stem Cell Self-Renewal
Neural stem cells (NSC) self-renew and are multipotent, producing neurons and glia. Recent studies have shown that brain tumors (BT) contain cells that, like NSC, self-renew and are multipotent, producing the different types of cells
Since the discovery of neural stem cells (NSC) in the embryonic and adult mammalian central nervous system (CNS), there have been a growing numbers of tissue culture media and protocols to study and functionally characterize NSCs
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