AZD-0284,2101291-07-8

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AZD-0284

CAS No. : 2101291-07-8

MCE 国际站：AZD-0284

产品活性：AZD-0284 是选择性的核受体 (RORγ) 的选择性反向激动剂。AZD-0284 具有用于斑块型寻常型银屑病和呼吸道疾病的潜力。

研究领域：Metabolic Enzyme/Protease  |  Vitamin D Related/Nuclear Receptor

作用靶点：ROR

In Vitro: AZD0284 (0.37 μM; 5 days) inhibits IL-17A production in human T_H17 cells.
AZD0284 reduces polarization of T_H17 into pathogenic T_H17/1 cells. AZD0284 decreases frequency of single IL-17⁺cell as well as double positive T_H17/1 cells. AZD0284 reduces IL-17A secretion and RNA expression of IL-17A, IL-17F, IL-22 and IL-23R.

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