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- MedChemExpress(MCE)
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- HY-112601
- 2025年12月05日
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货期：1-2天
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10 mM * 1 mL///1 mg
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IDH1 Inhibitor 1
CAS No. : 2234285-81-3
MCE 国际站：IDH1 Inhibitor 1
产品活性：IDH1 Inhibitor 1 是一种有效的，口服生物可利用的，脑渗透性，选择性突变 IDH1 抑制剂，抑制 IDH1R132H，IDH1R132C，和 IDH1WT，IC50 分别为 0.021 μM, 0.045 μM, 和 2.52 μM。具有抗肿瘤活性。
研究领域：Metabolic Enzyme/Protease
作用靶点：Isocitrate Dehydrogenase (IDH)
In Vitro: IDH1 Inhibitor 1 (Compound 19) inhibits cellular HCT116-IDH1R132H/+ with an IC50 of 0.039 μM.
In Vivo: IDH1 Inhibitor 1 (Compound 19) inhibits 2-hydroxyglutarate (2-HG) production in a preclinical xenograft tumor model. IDH1 Inhibitor 1 is also profiled in a patient-derived IDH1 mutant HCT116-IDH1R132H/+ mechanistic xenograft tumor model in mice to evaluate in vivo inhibition of 2-HG production. IDH1 Inhibitor 1, dosed orally at 150 mg/kg, inhibits new 2-HG production.
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文献和实验浅析染色质免疫沉淀（ChIP）技术在 DNA 与蛋白质相互作用研究中的重要性
analysis reveals genes associated with the ability of MYC to maintain tumorigenesis. PLoS Genet, 2008. 4(6): p. e1000090. [6] Guo, H., et al., Tissue factor pathway inhibitor-2 was repressed by CpG hypermethylation through inhibition of KLF6 binding
55µl Random Primer p(dN)9 , 0.2µg/µl 25µl 55µl RNase Inhibitor (a) , 40U/µl 20µl
Isolation of total RNA using CsCl/EtBr gradients--密度梯度法提取总RNA
. This method, which is simply lysis by Frech pressing in RNase inhibitor-containing buffer followed by phenol:chloroform extraction, EtOH precipitation & CsCl/EtBr isopycnic centrifugation, is relatively rapid, easy, & results in an undegraded RNA preparation
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