LMPTP inhibitor 1 dihydrochlor

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LMPTP inhibitor 1 dihydrochloride

CAS No. : 2310135-46-5

MCE 国际站：LMPTP inhibitor 1 dihydrochloride

产品活性：LMPTP INHIBITOR 1 (dihydrochloride) 是一种选择性的低分子量蛋白酪氨酸磷酸酶 (LMPTP) 抑制剂，能够抑制 LMPTP-A 的活性，IC₅₀ 值为 0.8 μM。

研究领域：Metabolic Enzyme/Protease

作用靶点：Phosphatase

In Vitro: LMPTP INHIBITOR 1 (dihydrochloride) is a selective inhibitor of low molecular weight protein tyrosine phosphatase, with an IC₅₀ of 0.8 μM LMPTP-A and shows more potent effect on LMPTP-A versus LMPTP-B. LMPTP inhibitor 1 (Compound 23; 10 μM) also enhances HepG2 IR phosphorylation after insulin stimulation in human HepG2 hepatocytes.

In Vivo: LMPTP inhibitor 1 is orally bioavailable, and results in appr 680 nM mean serum concentration after treatment of 0.03% w/w, while treatment with 0.05% w/w results in >3 μM; also reverses diabetes in obese mice. LMPTP inhibitor 1 (0.05% w/w) inhibits LMPTP activity, significantly improves glucose tolerance and decreases fasting insulin levels of diabetic DIO mice, without affecting body weight.

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