Cilofexor,1418274-28-8

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Cilofexor

CAS No. : 1418274-28-8

MCE 国际站：Cilofexor

产品活性：Cilofexor (GS-9674) 是一种有效的，选择性的，口服活性的非甾体 FXR 激动剂，EC₅₀ 为 43 nM。Cilofexor 具有抗炎和抗纤维化作用。Cilofexor 可用于原发性硬化性胆管炎 (PSC) 和非酒精性脂肪性肝炎 (NASH) 的研究。

研究领域：Metabolic Enzyme/Protease  |  Autophagy

作用靶点：FXR  |  Autophagy

In Vivo: Cilofexor (GS-9674; 30 mg/kg; oral gavage; once daily; for 10 weeks; male Wistar rats) treatment significantly increases Fgf15 expression in the ileum and decreased Cyp7a1 in the liver in nonalcoholic steatohepatitis (NASH) rats. Liver fibrosis and hepatic collagen expression are significantly reduced. Cilofexor also significantly reduces hepatic stellate cell (HSC) activation and significantly decreases portal pressure, without affecting systemic hemodynamics.

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