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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
GLPG1690
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥710.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥250.0 |
| 规格： | 5 mg | 产品价格： | ￥550.0 |
| 规格： | 10 mg | 产品价格： | ￥900.0 |
| 规格： | 25 mg | 产品价格： | ￥1500.0 |
| 规格： | 50 mg | 产品价格： | ￥2500.0 |
| 规格： | 100 mg | 产品价格： | ￥4500.0 |
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Ziritaxestat
CAS No. : 1628260-79-6
MCE 国际站：Ziritaxestat
产品活性：Ziritaxestat (GLPG1690) 是创新的 autotaxin (ATX) 抑制剂，IC50 和 Ki 值分别为 131 nM 和 15 nM。
研究领域：Metabolic Enzyme/Protease
作用靶点：Phosphodiesterase (PDE)
In Vitro: Ziritaxestat (GLPG1690) shows no CYP3A4 TDI and decreases hERG inhibitory activity with IC50 of 15 μM in manual patch clamp assay.
In Vivo: Ziritaxestat (GLPG1690) inhibits ATX-induced LPA 18:2 production in mouse, rat, and healthy donor plasma in a concentration-dependent manner, with IC50 values of 418 nM, 542 nM, and 242 nM, respectively.
Ziritaxestat (GLPG1690) displays improved pharmacokinetic properties, with a low plasma clearance and high bioavailability in mouse and rat. The good pharmacokinetic profile is further confirmed in dog, with Ziritaxestat (GLPG1690) showing low plasma clearance (0.12 L/h/kg) and a high bioavailability (63%).
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