RP 70676,136609-26-2

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RP 70676

CAS No. : 136609-26-2

MCE 国际站：RP 70676

产品活性：RP 70676 是一种有效的 ACAT 抑制剂，能够抑制对大鼠和兔子中的 ACAT 活性，IC₅₀ 值分别为 25 和 44 nM。

研究领域：Metabolic Enzyme/Protease

作用靶点：Acyltransferase

In Vitro: RP 70676 is a potent inhibitor of rabbit arterial ACAT (IC₅₀ = 40 nM) and has been shown to be an effective inhibitor of ACAT derived from a number of tissues and species including man. The IC₅₀ values range from 21 nM for hamster liver ACAT to 108 nM for enzyme from the intestine of cholesterol fed rabbits; in human hepatic tissues the mean IC₅₀ is 44 nM. In whole cell P388D, murine macrophages the compound has an IC₅₀ of 540 nM.

In Vivo: RP 70676 (10 mg/kg, p.o.) is well absorbed with plasma levels in NZW rabbits.

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