SR0987,303126-97-8

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SR0987

CAS No. : 303126-97-8

MCE 国际站：SR0987

产品活性：SR0987是SR1078 的一个类似物，是 RORγt 的一个激动剂，其 EC₅₀ 值为800 nM。SR0987 可上调IL17 的表达且抑制PD-1 的表达。

研究领域：Metabolic Enzyme/Protease  |  Vitamin D Related/Nuclear Receptor

作用靶点：ROR

In Vitro: SR0987 clearly shows a concentration dependent induction of reporter gene expression with an EC₅₀ of ~800nM. SR0987 treatment results in a statistically significant reduction of the surface expression of PD-1 whereas desmostrol treatment shows no effect. Treatment with SR0987 and or desmosterol results in a trend towards increased IL17 production.

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